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Differentiate w.r.t. x
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\frac{\frac{4x^{2}\times 12y^{3}}{3yx}}{-\frac{2}{9xy}}
Divide \frac{4x^{2}}{3y} by \frac{x}{12y^{3}} by multiplying \frac{4x^{2}}{3y} by the reciprocal of \frac{x}{12y^{3}}.
\frac{4\times 4xy^{2}}{-\frac{2}{9xy}}
Cancel out 3xy in both numerator and denominator.
\frac{16xy^{2}}{-\frac{2}{9xy}}
Multiply 4 and 4 to get 16.
\frac{-16xy^{2}}{\frac{2}{9xy}}
Cancel out -1 in both numerator and denominator.
\frac{-16xy^{2}\times 9xy}{2}
Divide -16xy^{2} by \frac{2}{9xy} by multiplying -16xy^{2} by the reciprocal of \frac{2}{9xy}.
\frac{-16x^{2}y^{2}\times 9y}{2}
Multiply x and x to get x^{2}.
\frac{-16x^{2}y^{3}\times 9}{2}
To multiply powers of the same base, add their exponents. Add 2 and 1 to get 3.
\frac{-144x^{2}y^{3}}{2}
Multiply -16 and 9 to get -144.
-72x^{2}y^{3}
Divide -144x^{2}y^{3} by 2 to get -72x^{2}y^{3}.