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Differentiate w.r.t. a
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\frac{4^{1}a^{6}b^{2}}{\left(-8\right)^{1}a^{3}b^{2}}
Use the rules of exponents to simplify the expression.
\frac{4^{1}}{\left(-8\right)^{1}}a^{6-3}b^{2-2}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{4^{1}}{\left(-8\right)^{1}}a^{3}b^{2-2}
Subtract 3 from 6.
\frac{4^{1}}{\left(-8\right)^{1}}a^{3}b^{0}
Subtract 2 from 2.
\frac{4^{1}}{\left(-8\right)^{1}}a^{3}
For any number a except 0, a^{0}=1.
-\frac{1}{2}a^{3}
Reduce the fraction \frac{4}{-8} to lowest terms by extracting and canceling out 4.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{4b^{2}}{-8b^{2}}a^{6-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(-\frac{1}{2}a^{3})
Do the arithmetic.
3\left(-\frac{1}{2}\right)a^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-\frac{3}{2}a^{2}
Do the arithmetic.