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Differentiate w.r.t. a
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\frac{4^{2}b^{-5}a^{8}}{b^{3}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{4^{2}a^{8}}{b^{8}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{16a^{8}}{b^{8}}
Calculate 4 to the power of 2 and get 16.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{4}{b^{5}\times \frac{b^{3}}{4}}a^{4-\left(-4\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{16}{b^{8}}a^{8})
Do the arithmetic.
8\times \frac{16}{b^{8}}a^{8-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{128}{b^{8}}a^{7}
Do the arithmetic.