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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{4b^{2}c^{2}}{-16c^{2}}a^{2-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\left(-\frac{b^{2}}{4}\right)\times \frac{1}{a})
Do the arithmetic.
-\left(-\frac{b^{2}}{4}\right)a^{-1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{b^{2}}{4}a^{-2}
Do the arithmetic.
\frac{b^{2}}{-4a}
Cancel out 4a^{2}c^{2} in both numerator and denominator.