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\frac{4x\left(x-2\right)\left(-x+4\right)\left(x^{2}+9\right)\left(x^{2}+2x+4\right)}{\left(x-2\right)\left(x+2\right)}
Factor the expressions that are not already factored.
\frac{4x\left(-x+4\right)\left(x^{2}+9\right)\left(x^{2}+2x+4\right)}{x+2}
Cancel out x-2 in both numerator and denominator.
\frac{-4x^{6}+8x^{5}-20x^{4}+136x^{3}+144x^{2}+576x}{x+2}
Expand the expression.
\frac{4x\left(x-2\right)\left(-x+4\right)\left(x^{2}+9\right)\left(x^{2}+2x+4\right)}{\left(x-2\right)\left(x+2\right)}
Factor the expressions that are not already factored.
\frac{4x\left(-x+4\right)\left(x^{2}+9\right)\left(x^{2}+2x+4\right)}{x+2}
Cancel out x-2 in both numerator and denominator.
\frac{-4x^{6}+8x^{5}-20x^{4}+136x^{3}+144x^{2}+576x}{x+2}
Expand the expression.