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Differentiate w.r.t. x
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\frac{4\left(x+4\right)}{\left(x-3\right)\left(x+4\right)}-\frac{5x\left(x-3\right)}{\left(x-3\right)\left(x+4\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of x-3 and x+4 is \left(x-3\right)\left(x+4\right). Multiply \frac{4}{x-3} times \frac{x+4}{x+4}. Multiply \frac{5x}{x+4} times \frac{x-3}{x-3}.
\frac{4\left(x+4\right)-5x\left(x-3\right)}{\left(x-3\right)\left(x+4\right)}
Since \frac{4\left(x+4\right)}{\left(x-3\right)\left(x+4\right)} and \frac{5x\left(x-3\right)}{\left(x-3\right)\left(x+4\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{4x+16-5x^{2}+15x}{\left(x-3\right)\left(x+4\right)}
Do the multiplications in 4\left(x+4\right)-5x\left(x-3\right).
\frac{19x+16-5x^{2}}{\left(x-3\right)\left(x+4\right)}
Combine like terms in 4x+16-5x^{2}+15x.
\frac{19x+16-5x^{2}}{x^{2}+x-12}
Expand \left(x-3\right)\left(x+4\right).