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Differentiate w.r.t. m
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\frac{4\left(m+6\right)}{\left(m+3\right)\left(m+6\right)}-\frac{9m\left(m+3\right)}{\left(m+3\right)\left(m+6\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of m+3 and m+6 is \left(m+3\right)\left(m+6\right). Multiply \frac{4}{m+3} times \frac{m+6}{m+6}. Multiply \frac{9m}{m+6} times \frac{m+3}{m+3}.
\frac{4\left(m+6\right)-9m\left(m+3\right)}{\left(m+3\right)\left(m+6\right)}
Since \frac{4\left(m+6\right)}{\left(m+3\right)\left(m+6\right)} and \frac{9m\left(m+3\right)}{\left(m+3\right)\left(m+6\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{4m+24-9m^{2}-27m}{\left(m+3\right)\left(m+6\right)}
Do the multiplications in 4\left(m+6\right)-9m\left(m+3\right).
\frac{-23m+24-9m^{2}}{\left(m+3\right)\left(m+6\right)}
Combine like terms in 4m+24-9m^{2}-27m.
\frac{-23m+24-9m^{2}}{m^{2}+9m+18}
Expand \left(m+3\right)\left(m+6\right).