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Differentiate w.r.t. a
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\frac{4}{9^{3}}a^{-\frac{4}{3}}
To multiply powers of the same base, add their exponents. Add -\frac{3}{2} and \frac{1}{6} to get -\frac{4}{3}.
\frac{4}{729}a^{-\frac{4}{3}}
Calculate 9 to the power of 3 and get 729.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{4}{9^{3}}a^{-\frac{4}{3}})
To multiply powers of the same base, add their exponents. Add -\frac{3}{2} and \frac{1}{6} to get -\frac{4}{3}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{4}{729}a^{-\frac{4}{3}})
Calculate 9 to the power of 3 and get 729.
-\frac{4}{3}\times \frac{4}{729}a^{-\frac{4}{3}-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{16}{2187}a^{-\frac{4}{3}-1}
Multiply -\frac{4}{3} times \frac{4}{729} by multiplying numerator times numerator and denominator times denominator. Then reduce the fraction to lowest terms if possible.
-\frac{16}{2187}a^{-\frac{7}{3}}
Subtract 1 from -\frac{4}{3}.