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\frac{16}{12}-\frac{121}{12}
Least common multiple of 3 and 12 is 12. Convert \frac{4}{3} and \frac{121}{12} to fractions with denominator 12.
\frac{16-121}{12}
Since \frac{16}{12} and \frac{121}{12} have the same denominator, subtract them by subtracting their numerators.
\frac{-105}{12}
Subtract 121 from 16 to get -105.
-\frac{35}{4}
Reduce the fraction \frac{-105}{12} to lowest terms by extracting and canceling out 3.