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\frac{4}{3}\left(\frac{2}{12}-\frac{27}{12}\right)
Least common multiple of 6 and 4 is 12. Convert \frac{1}{6} and \frac{9}{4} to fractions with denominator 12.
\frac{4}{3}\times \frac{2-27}{12}
Since \frac{2}{12} and \frac{27}{12} have the same denominator, subtract them by subtracting their numerators.
\frac{4}{3}\left(-\frac{25}{12}\right)
Subtract 27 from 2 to get -25.
\frac{4\left(-25\right)}{3\times 12}
Multiply \frac{4}{3} times -\frac{25}{12} by multiplying numerator times numerator and denominator times denominator.
\frac{-100}{36}
Do the multiplications in the fraction \frac{4\left(-25\right)}{3\times 12}.
-\frac{25}{9}
Reduce the fraction \frac{-100}{36} to lowest terms by extracting and canceling out 4.