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Differentiate w.r.t. a
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\frac{4^{5}a^{8}b^{3}}{4^{3}a^{3}b^{2}}
Use the rules of exponents to simplify the expression.
4^{5-3}a^{8-3}b^{3-2}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
4^{2}a^{8-3}b^{3-2}
Subtract 3 from 5.
16a^{5}b^{3-2}
Subtract 3 from 8.
16a^{5}b^{1}
Subtract 2 from 3.
16a^{5}b
For any term t, t^{1}=t.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1024b^{3}}{64b^{2}}a^{8-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(16ba^{5})
Do the arithmetic.
5\times 16ba^{5-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
80ba^{4}
Do the arithmetic.