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Differentiate w.r.t. x
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\frac{36x^{2}}{4\left(3x+4\right)}
Factor the expressions that are not already factored.
\frac{9x^{2}}{3x+4}
Cancel out 4 in both numerator and denominator.
\frac{\left(12x^{1}+16\right)\frac{\mathrm{d}}{\mathrm{d}x}(36x^{2})-36x^{2}\frac{\mathrm{d}}{\mathrm{d}x}(12x^{1}+16)}{\left(12x^{1}+16\right)^{2}}
For any two differentiable functions, the derivative of the quotient of two functions is the denominator times the derivative of the numerator minus the numerator times the derivative of the denominator, all divided by the denominator squared.
\frac{\left(12x^{1}+16\right)\times 2\times 36x^{2-1}-36x^{2}\times 12x^{1-1}}{\left(12x^{1}+16\right)^{2}}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{\left(12x^{1}+16\right)\times 72x^{1}-36x^{2}\times 12x^{0}}{\left(12x^{1}+16\right)^{2}}
Do the arithmetic.
\frac{12x^{1}\times 72x^{1}+16\times 72x^{1}-36x^{2}\times 12x^{0}}{\left(12x^{1}+16\right)^{2}}
Expand using distributive property.
\frac{12\times 72x^{1+1}+16\times 72x^{1}-36\times 12x^{2}}{\left(12x^{1}+16\right)^{2}}
To multiply powers of the same base, add their exponents.
\frac{864x^{2}+1152x^{1}-432x^{2}}{\left(12x^{1}+16\right)^{2}}
Do the arithmetic.
\frac{\left(864-432\right)x^{2}+1152x^{1}}{\left(12x^{1}+16\right)^{2}}
Combine like terms.
\frac{432x^{2}+1152x^{1}}{\left(12x^{1}+16\right)^{2}}
Subtract 432 from 864.
\frac{144x\left(3x^{1}+8x^{0}\right)}{\left(12x^{1}+16\right)^{2}}
Factor out 144x.
\frac{144x\left(3x+8x^{0}\right)}{\left(12x+16\right)^{2}}
For any term t, t^{1}=t.
\frac{144x\left(3x+8\times 1\right)}{\left(12x+16\right)^{2}}
For any term t except 0, t^{0}=1.
\frac{144x\left(3x+8\right)}{\left(12x+16\right)^{2}}
For any term t, t\times 1=t and 1t=t.