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Differentiate w.r.t. x
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\frac{3x\left(-4x+3\right)}{\left(-5x+2\right)\left(-4x+3\right)}-\frac{5\left(-5x+2\right)}{\left(-5x+2\right)\left(-4x+3\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of 2-5x and 3-4x is \left(-5x+2\right)\left(-4x+3\right). Multiply \frac{3x}{2-5x} times \frac{-4x+3}{-4x+3}. Multiply \frac{5}{3-4x} times \frac{-5x+2}{-5x+2}.
\frac{3x\left(-4x+3\right)-5\left(-5x+2\right)}{\left(-5x+2\right)\left(-4x+3\right)}
Since \frac{3x\left(-4x+3\right)}{\left(-5x+2\right)\left(-4x+3\right)} and \frac{5\left(-5x+2\right)}{\left(-5x+2\right)\left(-4x+3\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{-12x^{2}+9x+25x-10}{\left(-5x+2\right)\left(-4x+3\right)}
Do the multiplications in 3x\left(-4x+3\right)-5\left(-5x+2\right).
\frac{-12x^{2}+34x-10}{\left(-5x+2\right)\left(-4x+3\right)}
Combine like terms in -12x^{2}+9x+25x-10.
\frac{-12x^{2}+34x-10}{20x^{2}-23x+6}
Expand \left(-5x+2\right)\left(-4x+3\right).