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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3yz}{-6y^{5}}x^{4-1})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{z}{2y^{4}}\right)x^{3})
Do the arithmetic.
3\left(-\frac{z}{2y^{4}}\right)x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{3z}{2y^{4}}\right)x^{2}
Do the arithmetic.
\frac{zx^{3}}{-2y^{4}}
Cancel out 3xy in both numerator and denominator.