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Differentiate w.r.t. x
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\frac{3x^{3}y^{-3}z^{2}\times 4z^{3}\times 2z}{2x^{4}y^{4}}
To multiply powers of the same base, add their exponents. Add 2 and 1 to get 3.
\frac{3x^{3}y^{-3}z^{5}\times 4\times 2z}{2x^{4}y^{4}}
To multiply powers of the same base, add their exponents. Add 2 and 3 to get 5.
\frac{3x^{3}y^{-3}z^{6}\times 4\times 2}{2x^{4}y^{4}}
To multiply powers of the same base, add their exponents. Add 5 and 1 to get 6.
\frac{2\times 2\times 3y^{-3}z^{6}}{xy^{4}}
Cancel out 2x^{3} in both numerator and denominator.
\frac{2\times 2\times 3z^{6}}{xy^{7}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{4\times 3z^{6}}{xy^{7}}
Multiply 2 and 2 to get 4.
\frac{12z^{6}}{xy^{7}}
Multiply 4 and 3 to get 12.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{24xz^{6}}{y^{3}\times 2y^{4}}x^{2-4})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{12xz^{6}}{y^{7}}x^{-2})
Do the arithmetic.
-2\times \frac{12xz^{6}}{y^{7}}x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{24xz^{6}}{y^{7}}\right)x^{-3}
Do the arithmetic.