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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{3c^{3}b^{9}}{cb^{8}}a^{4-1})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(3bc^{2}a^{3})
Do the arithmetic.
3\times 3bc^{2}a^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
9bc^{2}a^{2}
Do the arithmetic.
3bc^{2}a^{3}
Cancel out acb^{8} in both numerator and denominator.