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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3y^{8}z^{8}}{7\left(-\frac{y^{6}z^{6}}{4}\right)}x^{3-5})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{12y^{2}z^{2}}{7}\right)x^{-2})
Do the arithmetic.
-2\left(-\frac{12y^{2}z^{2}}{7}\right)x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{24y^{2}z^{2}}{7}x^{-3}
Do the arithmetic.
\frac{\frac{3}{7}y^{2}z^{2}}{-\frac{1}{4}x^{2}}
Cancel out x^{3}y^{6}z^{6} in both numerator and denominator.