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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{28z^{10}y^{12}}{4yz^{5}}x^{5-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(7z^{5}y^{11}x^{2})
Do the arithmetic.
2\times 7z^{5}y^{11}x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
14z^{5}y^{11}x^{1}
Do the arithmetic.
14z^{5}y^{11}x
For any term t, t^{1}=t.
7x^{2}z^{5}y^{11}
Cancel out 4yx^{3}z^{5} in both numerator and denominator.