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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{24yz}{36yz}x^{1-5})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{2}{3}x^{-4})
Do the arithmetic.
-4\times \frac{2}{3}x^{-4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-\frac{8}{3}x^{-5}
Do the arithmetic.
\frac{2}{3x^{4}}
Cancel out 12xyz in both numerator and denominator.