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Differentiate w.r.t. x
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\frac{2x}{\left(x-8y\right)\left(x+8y\right)}-\frac{1}{x-8y}
Factor x^{2}-64y^{2}.
\frac{2x}{\left(x-8y\right)\left(x+8y\right)}-\frac{x+8y}{\left(x-8y\right)\left(x+8y\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of \left(x-8y\right)\left(x+8y\right) and x-8y is \left(x-8y\right)\left(x+8y\right). Multiply \frac{1}{x-8y} times \frac{x+8y}{x+8y}.
\frac{2x-\left(x+8y\right)}{\left(x-8y\right)\left(x+8y\right)}
Since \frac{2x}{\left(x-8y\right)\left(x+8y\right)} and \frac{x+8y}{\left(x-8y\right)\left(x+8y\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{2x-x-8y}{\left(x-8y\right)\left(x+8y\right)}
Do the multiplications in 2x-\left(x+8y\right).
\frac{x-8y}{\left(x-8y\right)\left(x+8y\right)}
Combine like terms in 2x-x-8y.
\frac{1}{x+8y}
Cancel out x-8y in both numerator and denominator.