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Differentiate w.r.t. x
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\frac{2x^{2}y^{2}}{4x^{2}+2401\times 3x^{-3}}
Calculate 7 to the power of 4 and get 2401.
\frac{2x^{2}y^{2}}{4x^{2}+7203x^{-3}}
Multiply 2401 and 3 to get 7203.
\frac{2x^{2}y^{2}}{x^{-3}\left(4x^{5}+7203\right)}
Factor the expressions that are not already factored.
\frac{2y^{2}x^{5}}{4x^{5}+7203}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\left(4x^{2}+7203x^{-3}\right)\frac{\mathrm{d}}{\mathrm{d}x}(2y^{2}x^{2})-2y^{2}x^{2}\frac{\mathrm{d}}{\mathrm{d}x}(4x^{2}+7203x^{-3})}{\left(4x^{2}+7203x^{-3}\right)^{2}}
For any two differentiable functions, the derivative of the quotient of two functions is the denominator times the derivative of the numerator minus the numerator times the derivative of the denominator, all divided by the denominator squared.
\frac{\left(4x^{2}+7203x^{-3}\right)\times 2\times 2y^{2}x^{2-1}-2y^{2}x^{2}\left(2\times 4x^{2-1}-3\times 7203x^{-3-1}\right)}{\left(4x^{2}+7203x^{-3}\right)^{2}}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{\left(4x^{2}+7203x^{-3}\right)\times 4y^{2}x^{1}-2y^{2}x^{2}\left(8x^{1}-21609x^{-4}\right)}{\left(4x^{2}+7203x^{-3}\right)^{2}}
Simplify.
\frac{4x^{2}\times 4y^{2}x^{1}+7203x^{-3}\times 4y^{2}x^{1}-2y^{2}x^{2}\left(8x^{1}-21609x^{-4}\right)}{\left(4x^{2}+7203x^{-3}\right)^{2}}
Multiply 4x^{2}+7203x^{-3} times 4y^{2}x^{1}.
\frac{4x^{2}\times 4y^{2}x^{1}+7203x^{-3}\times 4y^{2}x^{1}-\left(2y^{2}x^{2}\times 8x^{1}+2y^{2}x^{2}\left(-21609\right)x^{-4}\right)}{\left(4x^{2}+7203x^{-3}\right)^{2}}
Multiply 2y^{2}x^{2} times 8x^{1}-21609x^{-4}.
\frac{4\times 4y^{2}x^{2+1}+7203\times 4y^{2}x^{-3+1}-\left(2y^{2}\times 8x^{2+1}+2y^{2}\left(-21609\right)x^{2-4}\right)}{\left(4x^{2}+7203x^{-3}\right)^{2}}
To multiply powers of the same base, add their exponents.
\frac{16y^{2}x^{3}+28812y^{2}x^{-2}-\left(16y^{2}x^{3}+\left(-43218y^{2}\right)x^{-2}\right)}{\left(4x^{2}+7203x^{-3}\right)^{2}}
Simplify.
\frac{72030y^{2}x^{-2}}{\left(4x^{2}+7203x^{-3}\right)^{2}}
Combine like terms.