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\frac{\left(x-4\right)\left(2x+3\right)}{\left(2x+1\right)\left(2x+3\right)}\times \frac{x^{2}-16}{2x^{2}+7x+3}
Factor the expressions that are not already factored in \frac{2x^{2}-5x-12}{4x^{2}+8x+3}.
\frac{x-4}{2x+1}\times \frac{x^{2}-16}{2x^{2}+7x+3}
Cancel out 2x+3 in both numerator and denominator.
\frac{\left(x-4\right)\left(x^{2}-16\right)}{\left(2x+1\right)\left(2x^{2}+7x+3\right)}
Multiply \frac{x-4}{2x+1} times \frac{x^{2}-16}{2x^{2}+7x+3} by multiplying numerator times numerator and denominator times denominator.
\frac{x^{3}-16x-4x^{2}+64}{\left(2x+1\right)\left(2x^{2}+7x+3\right)}
Use the distributive property to multiply x-4 by x^{2}-16.
\frac{x^{3}-16x-4x^{2}+64}{4x^{3}+16x^{2}+13x+3}
Use the distributive property to multiply 2x+1 by 2x^{2}+7x+3 and combine like terms.
\frac{\left(x-4\right)\left(2x+3\right)}{\left(2x+1\right)\left(2x+3\right)}\times \frac{x^{2}-16}{2x^{2}+7x+3}
Factor the expressions that are not already factored in \frac{2x^{2}-5x-12}{4x^{2}+8x+3}.
\frac{x-4}{2x+1}\times \frac{x^{2}-16}{2x^{2}+7x+3}
Cancel out 2x+3 in both numerator and denominator.
\frac{\left(x-4\right)\left(x^{2}-16\right)}{\left(2x+1\right)\left(2x^{2}+7x+3\right)}
Multiply \frac{x-4}{2x+1} times \frac{x^{2}-16}{2x^{2}+7x+3} by multiplying numerator times numerator and denominator times denominator.
\frac{x^{3}-16x-4x^{2}+64}{\left(2x+1\right)\left(2x^{2}+7x+3\right)}
Use the distributive property to multiply x-4 by x^{2}-16.
\frac{x^{3}-16x-4x^{2}+64}{4x^{3}+16x^{2}+13x+3}
Use the distributive property to multiply 2x+1 by 2x^{2}+7x+3 and combine like terms.