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\frac{\left(2x^{2}-10\right)\left(x-4\right)}{\left(x+1\right)\left(4x^{2}-20\right)}
Multiply \frac{2x^{2}-10}{x+1} times \frac{x-4}{4x^{2}-20} by multiplying numerator times numerator and denominator times denominator.
\frac{2\left(x-4\right)\left(x^{2}-5\right)}{4\left(x+1\right)\left(x^{2}-5\right)}
Factor the expressions that are not already factored.
\frac{x-4}{2\left(x+1\right)}
Cancel out 2\left(x^{2}-5\right) in both numerator and denominator.
\frac{x-4}{2x+2}
Expand the expression.
\frac{\left(2x^{2}-10\right)\left(x-4\right)}{\left(x+1\right)\left(4x^{2}-20\right)}
Multiply \frac{2x^{2}-10}{x+1} times \frac{x-4}{4x^{2}-20} by multiplying numerator times numerator and denominator times denominator.
\frac{2\left(x-4\right)\left(x^{2}-5\right)}{4\left(x+1\right)\left(x^{2}-5\right)}
Factor the expressions that are not already factored.
\frac{x-4}{2\left(x+1\right)}
Cancel out 2\left(x^{2}-5\right) in both numerator and denominator.
\frac{x-4}{2x+2}
Expand the expression.