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\frac{2\left(x-1\right)\left(x+4\right)}{4\left(x+2\right)\left(-x+1\right)}
Factor the expressions that are not already factored.
\frac{-2\left(x+4\right)\left(-x+1\right)}{4\left(x+2\right)\left(-x+1\right)}
Extract the negative sign in -1+x.
\frac{-\left(x+4\right)}{2\left(x+2\right)}
Cancel out 2\left(-x+1\right) in both numerator and denominator.
\frac{-x-4}{2x+4}
Expand the expression.
\frac{2\left(x-1\right)\left(x+4\right)}{4\left(x+2\right)\left(-x+1\right)}
Factor the expressions that are not already factored.
\frac{-2\left(x+4\right)\left(-x+1\right)}{4\left(x+2\right)\left(-x+1\right)}
Extract the negative sign in -1+x.
\frac{-\left(x+4\right)}{2\left(x+2\right)}
Cancel out 2\left(-x+1\right) in both numerator and denominator.
\frac{-x-4}{2x+4}
Expand the expression.