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Differentiate w.r.t. x
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\frac{2x^{-3}y^{-3}}{\left(x^{2}\right)^{-\frac{1}{6}}\left(y^{4}\right)^{-\frac{1}{6}}}
Expand \left(x^{2}y^{4}\right)^{-\frac{1}{6}}.
\frac{2x^{-3}y^{-3}}{x^{-\frac{1}{3}}\left(y^{4}\right)^{-\frac{1}{6}}}
To raise a power to another power, multiply the exponents. Multiply 2 and -\frac{1}{6} to get -\frac{1}{3}.
\frac{2x^{-3}y^{-3}}{x^{-\frac{1}{3}}y^{-\frac{2}{3}}}
To raise a power to another power, multiply the exponents. Multiply 4 and -\frac{1}{6} to get -\frac{2}{3}.
\frac{2}{y^{\frac{7}{3}}x^{\frac{8}{3}}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.