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Differentiate w.r.t. a
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\frac{c^{-5}a^{2}b^{3}}{5a^{-3}\times \frac{1}{b}c^{2}}
Cancel out 2 in both numerator and denominator.
\frac{c^{-5}b^{4}a^{5}}{5c^{2}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{b^{4}a^{5}}{5c^{7}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{2b^{3}}{c^{5}\times \frac{10c^{2}}{b}}a^{2-\left(-3\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{b^{4}}{5c^{7}}a^{5})
Do the arithmetic.
5\times \frac{b^{4}}{5c^{7}}a^{5-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{b^{4}}{c^{7}}a^{4}
Do the arithmetic.