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Differentiate w.r.t. a
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\frac{b^{-7}a^{2}c^{10}}{3a^{-3}c^{-3}b^{2}}
Cancel out 2 in both numerator and denominator.
\frac{b^{-7}a^{5}c^{13}}{3b^{2}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{a^{5}c^{13}}{3b^{9}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{2c^{10}}{b^{7}\times \frac{6b^{2}}{c^{3}}}a^{2-\left(-3\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{c^{13}}{3b^{9}}a^{5})
Do the arithmetic.
5\times \frac{c^{13}}{3b^{9}}a^{5-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{5c^{13}}{3b^{9}}a^{4}
Do the arithmetic.