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20\times 2\left(5x-3\right)-10\times 5\left(x-6\right)=15\times 3\left(2x+1\right)-12\times 4\times 3x
Multiply both sides of the equation by 60, the least common multiple of 3,6,4,5.
40\left(5x-3\right)-10\times 5\left(x-6\right)=15\times 3\left(2x+1\right)-12\times 4\times 3x
Multiply 20 and 2 to get 40.
200x-120-10\times 5\left(x-6\right)=15\times 3\left(2x+1\right)-12\times 4\times 3x
Use the distributive property to multiply 40 by 5x-3.
200x-120-50\left(x-6\right)=15\times 3\left(2x+1\right)-12\times 4\times 3x
Multiply -10 and 5 to get -50.
200x-120-50x+300=15\times 3\left(2x+1\right)-12\times 4\times 3x
Use the distributive property to multiply -50 by x-6.
150x-120+300=15\times 3\left(2x+1\right)-12\times 4\times 3x
Combine 200x and -50x to get 150x.
150x+180=15\times 3\left(2x+1\right)-12\times 4\times 3x
Add -120 and 300 to get 180.
150x+180=45\left(2x+1\right)-48\times 3x
Multiply 15 and 3 to get 45. Multiply -12 and 4 to get -48.
150x+180=90x+45-48\times 3x
Use the distributive property to multiply 45 by 2x+1.
150x+180=90x+45-144x
Multiply -48 and 3 to get -144.
150x+180=-54x+45
Combine 90x and -144x to get -54x.
150x+180+54x=45
Add 54x to both sides.
204x+180=45
Combine 150x and 54x to get 204x.
204x=45-180
Subtract 180 from both sides.
204x=-135
Subtract 180 from 45 to get -135.
x=\frac{-135}{204}
Divide both sides by 204.
x=-\frac{45}{68}
Reduce the fraction \frac{-135}{204} to lowest terms by extracting and canceling out 3.