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\frac{2^{-8}\times 4^{2}}{2^{5}\times 3^{2}}
Cancel out 3^{5} in both numerator and denominator.
\frac{4^{2}}{2^{13}\times 3^{2}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{16}{2^{13}\times 3^{2}}
Calculate 4 to the power of 2 and get 16.
\frac{16}{8192\times 3^{2}}
Calculate 2 to the power of 13 and get 8192.
\frac{16}{8192\times 9}
Calculate 3 to the power of 2 and get 9.
\frac{16}{73728}
Multiply 8192 and 9 to get 73728.
\frac{1}{4608}
Reduce the fraction \frac{16}{73728} to lowest terms by extracting and canceling out 16.