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\frac{2^{1}}{2^{-3}}
To multiply powers of the same base, add their exponents. Add -4 and 5 to get 1.
2^{4}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent. Subtract -3 from 1 to get 4.
16
Calculate 2 to the power of 4 and get 16.