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Differentiate w.r.t. x
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\frac{2^{-2}y^{-4}}{5^{-2}\times \frac{1}{y}x^{5}}
Cancel out x^{2} in both numerator and denominator.
\frac{2^{-2}}{5^{-2}y^{3}x^{5}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\frac{1}{4}}{5^{-2}y^{3}x^{5}}
Calculate 2 to the power of -2 and get \frac{1}{4}.
\frac{\frac{1}{4}}{\frac{1}{25}y^{3}x^{5}}
Calculate 5 to the power of -2 and get \frac{1}{25}.
\frac{1}{4\times \frac{1}{25}y^{3}x^{5}}
Express \frac{\frac{1}{4}}{\frac{1}{25}y^{3}x^{5}} as a single fraction.
\frac{1}{\frac{4}{25}y^{3}x^{5}}
Multiply 4 and \frac{1}{25} to get \frac{4}{25}.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{4y^{4}\times \frac{1}{25y}}x^{2-7})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{25}{4y^{3}}x^{-5})
Do the arithmetic.
-5\times \frac{25}{4y^{3}}x^{-5-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{125}{4y^{3}}\right)x^{-6}
Do the arithmetic.