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16\times 2\left(\left(x-4\right)\left(2x-1\right)+7\right)-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)=16x^{2}+352-48x+51
Multiply both sides of the equation by 48, the least common multiple of 3,4,16.
32\left(\left(x-4\right)\left(2x-1\right)+7\right)-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)=16x^{2}+352-48x+51
Multiply 16 and 2 to get 32.
32\left(2x^{2}-9x+4+7\right)-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)=16x^{2}+352-48x+51
Use the distributive property to multiply x-4 by 2x-1 and combine like terms.
32\left(2x^{2}-9x+11\right)-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)=16x^{2}+352-48x+51
Add 4 and 7 to get 11.
64x^{2}-288x+352-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)=16x^{2}+352-48x+51
Use the distributive property to multiply 32 by 2x^{2}-9x+11.
64x^{2}-288x+352-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)=16x^{2}+403-48x
Add 352 and 51 to get 403.
64x^{2}-288x+352-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)-16x^{2}=403-48x
Subtract 16x^{2} from both sides.
64x^{2}-288x+352-48\left(x-\frac{1}{4}\right)\left(\frac{1}{4}+x\right)-16x^{2}+48x=403
Add 48x to both sides.
64x^{2}-288x+352+\left(-48x+12\right)\left(\frac{1}{4}+x\right)-16x^{2}+48x=403
Use the distributive property to multiply -48 by x-\frac{1}{4}.
64x^{2}-288x+352-48x^{2}+3-16x^{2}+48x=403
Use the distributive property to multiply -48x+12 by \frac{1}{4}+x and combine like terms.
16x^{2}-288x+352+3-16x^{2}+48x=403
Combine 64x^{2} and -48x^{2} to get 16x^{2}.
16x^{2}-288x+355-16x^{2}+48x=403
Add 352 and 3 to get 355.
-288x+355+48x=403
Combine 16x^{2} and -16x^{2} to get 0.
-240x+355=403
Combine -288x and 48x to get -240x.
-240x=403-355
Subtract 355 from both sides.
-240x=48
Subtract 355 from 403 to get 48.
x=\frac{48}{-240}
Divide both sides by -240.
x=-\frac{1}{5}
Reduce the fraction \frac{48}{-240} to lowest terms by extracting and canceling out 48.