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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{18y^{2}z^{3}}{3zy^{2}}x^{5-7})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(6z^{2}x^{-2})
Do the arithmetic.
-2\times 6z^{2}x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-12z^{2}\right)x^{-3}
Do the arithmetic.
\frac{6z^{2}}{x^{2}}
Cancel out 3zy^{2}x^{5} in both numerator and denominator.