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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{18c^{3}b^{4}}{12b^{2}c^{3}}a^{1-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{3b^{2}}{2}a^{-2})
Do the arithmetic.
-2\times \frac{3b^{2}}{2}a^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-3b^{2}\right)a^{-3}
Do the arithmetic.
\frac{3b^{2}}{2a^{2}}
Cancel out 6ab^{2}c^{3} in both numerator and denominator.