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\frac{16^{-1}\times 27^{-1}\times 81^{\frac{1}{4}}}{16^{-2}\times 27^{-\frac{4}{2}}\times 81^{\frac{2}{4}}}
Divide 2 by 2 to get 1.
\frac{\frac{1}{16}\times 27^{-1}\times 81^{\frac{1}{4}}}{16^{-2}\times 27^{-\frac{4}{2}}\times 81^{\frac{2}{4}}}
Calculate 16 to the power of -1 and get \frac{1}{16}.
\frac{\frac{1}{16}\times \frac{1}{27}\times 81^{\frac{1}{4}}}{16^{-2}\times 27^{-\frac{4}{2}}\times 81^{\frac{2}{4}}}
Calculate 27 to the power of -1 and get \frac{1}{27}.
\frac{\frac{1}{432}\times 81^{\frac{1}{4}}}{16^{-2}\times 27^{-\frac{4}{2}}\times 81^{\frac{2}{4}}}
Multiply \frac{1}{16} and \frac{1}{27} to get \frac{1}{432}.
\frac{\frac{1}{432}\times 3}{16^{-2}\times 27^{-\frac{4}{2}}\times 81^{\frac{2}{4}}}
Calculate 81 to the power of \frac{1}{4} and get 3.
\frac{\frac{1}{144}}{16^{-2}\times 27^{-\frac{4}{2}}\times 81^{\frac{2}{4}}}
Multiply \frac{1}{432} and 3 to get \frac{1}{144}.
\frac{\frac{1}{144}}{\frac{1}{256}\times 27^{-\frac{4}{2}}\times 81^{\frac{2}{4}}}
Calculate 16 to the power of -2 and get \frac{1}{256}.
\frac{\frac{1}{144}}{\frac{1}{256}\times 27^{-2}\times 81^{\frac{2}{4}}}
Divide 4 by 2 to get 2.
\frac{\frac{1}{144}}{\frac{1}{256}\times \frac{1}{729}\times 81^{\frac{2}{4}}}
Calculate 27 to the power of -2 and get \frac{1}{729}.
\frac{\frac{1}{144}}{\frac{1}{186624}\times 81^{\frac{2}{4}}}
Multiply \frac{1}{256} and \frac{1}{729} to get \frac{1}{186624}.
\frac{\frac{1}{144}}{\frac{1}{186624}\times 81^{\frac{1}{2}}}
Reduce the fraction \frac{2}{4} to lowest terms by extracting and canceling out 2.
\frac{\frac{1}{144}}{\frac{1}{186624}\times 9}
Calculate 81 to the power of \frac{1}{2} and get 9.
\frac{\frac{1}{144}}{\frac{1}{20736}}
Multiply \frac{1}{186624} and 9 to get \frac{1}{20736}.
\frac{1}{144}\times 20736
Divide \frac{1}{144} by \frac{1}{20736} by multiplying \frac{1}{144} by the reciprocal of \frac{1}{20736}.
144
Multiply \frac{1}{144} and 20736 to get 144.