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Evaluate
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Differentiate w.r.t. x
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\frac{3z^{-6}x^{-5}y^{8}}{-y^{-4}x^{-3}z^{-2}}
Cancel out 4 in both numerator and denominator.
\frac{3z^{-6}x^{-5}y^{12}}{-x^{-3}z^{-2}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{3y^{12}}{-x^{2}z^{4}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{-3y^{12}}{x^{2}z^{4}}
Cancel out -1 in both numerator and denominator.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{12y^{8}}{z^{6}\left(-\frac{4}{z^{2}y^{4}}\right)}x^{-5-\left(-3\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{3y^{12}}{z^{4}}\right)x^{-2})
Do the arithmetic.
-2\left(-\frac{3y^{12}}{z^{4}}\right)x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{6y^{12}}{z^{4}}x^{-3}
Do the arithmetic.