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\frac{100-x^{2}}{x-5}\times \frac{3}{x+10}\times \frac{2\left(x-5\right)\left(x+5\right)}{\left(x-10\right)\left(x+5\right)}
Factor the expressions that are not already factored in \frac{2x^{2}-50}{x^{2}-5x-50}.
\frac{100-x^{2}}{x-5}\times \frac{3}{x+10}\times \frac{2\left(x-5\right)}{x-10}
Cancel out x+5 in both numerator and denominator.
\frac{\left(100-x^{2}\right)\times 3}{\left(x-5\right)\left(x+10\right)}\times \frac{2\left(x-5\right)}{x-10}
Multiply \frac{100-x^{2}}{x-5} times \frac{3}{x+10} by multiplying numerator times numerator and denominator times denominator.
\frac{\left(100-x^{2}\right)\times 3\times 2\left(x-5\right)}{\left(x-5\right)\left(x+10\right)\left(x-10\right)}
Multiply \frac{\left(100-x^{2}\right)\times 3}{\left(x-5\right)\left(x+10\right)} times \frac{2\left(x-5\right)}{x-10} by multiplying numerator times numerator and denominator times denominator.
\frac{2\times 3\left(-x^{2}+100\right)}{\left(x-10\right)\left(x+10\right)}
Cancel out x-5 in both numerator and denominator.
\frac{6\left(-x^{2}+100\right)}{\left(x-10\right)\left(x+10\right)}
Multiply 2 and 3 to get 6.
\frac{6\left(x-10\right)\left(-x-10\right)}{\left(x-10\right)\left(x+10\right)}
Factor the expressions that are not already factored.
\frac{-6\left(x-10\right)\left(x+10\right)}{\left(x-10\right)\left(x+10\right)}
Extract the negative sign in -10-x.
-6
Cancel out \left(x-10\right)\left(x+10\right) in both numerator and denominator.