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Differentiate w.r.t. p
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\frac{10p^{6}q^{3}\times 2q^{3}}{5p^{8}q^{3}}
To multiply powers of the same base, add their exponents. Add 4 and 2 to get 6.
\frac{10p^{6}q^{6}\times 2}{5p^{8}q^{3}}
To multiply powers of the same base, add their exponents. Add 3 and 3 to get 6.
\frac{2\times 2q^{3}}{p^{2}}
Cancel out 5q^{3}p^{6} in both numerator and denominator.
\frac{4q^{3}}{p^{2}}
Multiply 2 and 2 to get 4.
\frac{\mathrm{d}}{\mathrm{d}p}(\frac{20p^{2}q^{6}}{5q^{3}}p^{4-8})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}p}(4p^{2}q^{3}p^{-4})
Do the arithmetic.
-4\times 4p^{2}q^{3}p^{-4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-16p^{2}q^{3}\right)p^{-5}
Do the arithmetic.