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\frac{1}{64}-\frac{16}{64}
Least common multiple of 64 and 4 is 64. Convert \frac{1}{64} and \frac{1}{4} to fractions with denominator 64.
\frac{1-16}{64}
Since \frac{1}{64} and \frac{16}{64} have the same denominator, subtract them by subtracting their numerators.
-\frac{15}{64}
Subtract 16 from 1 to get -15.