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\frac{\left(-x^{2}\right)x^{2}}{16}-25y^{2}
Express \frac{-x^{2}}{16}x^{2} as a single fraction.
\frac{\left(-x^{2}\right)x^{2}}{16}+\frac{16\left(-25\right)y^{2}}{16}
To add or subtract expressions, expand them to make their denominators the same. Multiply -25y^{2} times \frac{16}{16}.
\frac{\left(-x^{2}\right)x^{2}+16\left(-25\right)y^{2}}{16}
Since \frac{\left(-x^{2}\right)x^{2}}{16} and \frac{16\left(-25\right)y^{2}}{16} have the same denominator, add them by adding their numerators.
\frac{-x^{4}-400y^{2}}{16}
Do the multiplications in \left(-x^{2}\right)x^{2}+16\left(-25\right)y^{2}.
\frac{-x^{2}x^{2}-400y^{2}}{16}
Factor out \frac{1}{16}.