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Differentiate w.r.t. x
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\left(-x^{130}\right)^{1}\times \frac{1}{x^{216}}
Use the rules of exponents to simplify the expression.
-\left(x^{130}\right)^{1}\times \frac{1}{1}\times \frac{1}{x^{216}}
To raise the product of two or more numbers to a power, raise each number to the power and take their product.
-\frac{1}{1}\left(x^{130}\right)^{1}\times \frac{1}{x^{216}}
Use the Commutative Property of Multiplication.
-\frac{1}{1}x^{130}x^{216\left(-1\right)}
To raise a power to another power, multiply the exponents.
-\frac{1}{1}x^{130}x^{-216}
Multiply 216 times -1.
-\frac{1}{1}x^{130-216}
To multiply powers of the same base, add their exponents.
-\frac{1}{1}x^{-86}
Add the exponents 130 and -216.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{1}{1}\right)x^{130-216})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(-x^{-86})
Do the arithmetic.
-86\left(-1\right)x^{-86-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
86x^{-87}
Do the arithmetic.