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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{80z^{3}y^{5}}{60z^{2}y^{5}}\right)x^{4-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{4z}{3}\right)x^{2})
Do the arithmetic.
2\left(-\frac{4z}{3}\right)x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{8z}{3}\right)x^{1}
Do the arithmetic.
\left(-\frac{8z}{3}\right)x
For any term t, t^{1}=t.
\frac{-4zx^{2}}{3}
Cancel out 20x^{2}z^{2}y^{5} in both numerator and denominator.