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Differentiate w.r.t. p
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\frac{\left(-8\right)^{1}p^{2}q^{3}}{\left(-32\right)^{1}p^{3}q^{3}}
Use the rules of exponents to simplify the expression.
\frac{\left(-8\right)^{1}}{\left(-32\right)^{1}}p^{2-3}q^{3-3}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\left(-8\right)^{1}}{\left(-32\right)^{1}}\times \frac{1}{p}q^{3-3}
Subtract 3 from 2.
\frac{\left(-8\right)^{1}}{\left(-32\right)^{1}}\times \frac{1}{p}q^{0}
Subtract 3 from 3.
\frac{\left(-8\right)^{1}}{\left(-32\right)^{1}}\times \frac{1}{p}
For any number a except 0, a^{0}=1.
\frac{1}{4}\times \frac{1}{p}
Reduce the fraction \frac{-8}{-32} to lowest terms by extracting and canceling out 8.
\frac{\mathrm{d}}{\mathrm{d}p}(\left(-\frac{8q^{3}}{-32q^{3}}\right)p^{2-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}p}(\frac{1}{4}\times \frac{1}{p})
Do the arithmetic.
-\frac{1}{4}p^{-1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-\frac{1}{4}p^{-2}
Do the arithmetic.