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Differentiate w.r.t. x
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\frac{\left(-64\right)^{1}x^{3}y^{3}}{\left(-42\right)^{1}x^{9}y^{11}}
Use the rules of exponents to simplify the expression.
\frac{\left(-64\right)^{1}}{\left(-42\right)^{1}}x^{3-9}y^{3-11}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\left(-64\right)^{1}}{\left(-42\right)^{1}}x^{-6}y^{3-11}
Subtract 9 from 3.
\frac{\left(-64\right)^{1}}{\left(-42\right)^{1}}\times \frac{1}{x^{6}}y^{-8}
Subtract 11 from 3.
\frac{32}{21}\times \frac{1}{x^{6}}\times \frac{1}{y^{8}}
Reduce the fraction \frac{-64}{-42} to lowest terms by extracting and canceling out 2.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{64y^{3}}{-42y^{11}}\right)x^{3-9})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{32}{21y^{8}}x^{-6})
Do the arithmetic.
-6\times \frac{32}{21y^{8}}x^{-6-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{64}{7y^{8}}\right)x^{-7}
Do the arithmetic.