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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{52zy^{2}}{13y^{2}}\right)x^{3-1})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-4z\right)x^{2})
Do the arithmetic.
2\left(-4z\right)x^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-8z\right)x^{1}
Do the arithmetic.
\left(-8z\right)x
For any term t, t^{1}=t.
-4zx^{2}
Cancel out 13xy^{2} in both numerator and denominator.