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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{48yz^{2}}{64zy^{2}}\right)x^{2-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{3z}{4y}\right)\times \frac{1}{x})
Do the arithmetic.
-\left(-\frac{3z}{4y}\right)x^{-1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{3z}{4y}x^{-2}
Do the arithmetic.
\frac{-3z}{4xy}
Cancel out 16yzx^{2} in both numerator and denominator.