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Differentiate w.r.t. a
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\frac{-36a^{7}b^{5}c^{3}\times 44abc^{2}}{40ab^{3}c^{2}\times 27a^{3}b^{5}c^{8}}
Divide \frac{-36a^{7}b^{5}c^{3}}{40ab^{3}c^{2}} by \frac{27a^{3}b^{5}c^{8}}{44abc^{2}} by multiplying \frac{-36a^{7}b^{5}c^{3}}{40ab^{3}c^{2}} by the reciprocal of \frac{27a^{3}b^{5}c^{8}}{44abc^{2}}.
\frac{-22aa^{3}}{3\times 5b^{2}c^{5}}
Cancel out 2\times 4\times 9abcb^{2}c^{2}c^{2}a^{3}b^{3} in both numerator and denominator.
\frac{-22a^{4}}{3\times 5b^{2}c^{5}}
To multiply powers of the same base, add their exponents. Add 1 and 3 to get 4.
\frac{-22a^{4}}{15b^{2}c^{5}}
Multiply 3 and 5 to get 15.