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Differentiate w.r.t. x
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\frac{-2x^{5}yz^{3}\times 9yz^{4}}{\left(-6x\right)^{2}y^{0}z^{7}}
To multiply powers of the same base, add their exponents. Add 4 and 1 to get 5.
\frac{-2x^{5}y^{2}z^{3}\times 9z^{4}}{\left(-6x\right)^{2}y^{0}z^{7}}
Multiply y and y to get y^{2}.
\frac{-2x^{5}y^{2}z^{7}\times 9}{\left(-6x\right)^{2}y^{0}z^{7}}
To multiply powers of the same base, add their exponents. Add 3 and 4 to get 7.
\frac{-2\times 9y^{2}x^{5}}{y^{0}\left(-6x\right)^{2}}
Cancel out z^{7} in both numerator and denominator.
\frac{-2\times 9y^{2}x^{5}}{\left(-6x\right)^{2}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{-18y^{2}x^{5}}{\left(-6x\right)^{2}}
Multiply -2 and 9 to get -18.
\frac{-18y^{2}x^{5}}{\left(-6\right)^{2}x^{2}}
Expand \left(-6x\right)^{2}.
\frac{-18y^{2}x^{5}}{36x^{2}}
Calculate -6 to the power of 2 and get 36.
\frac{-y^{2}x^{3}}{2}
Cancel out 18x^{2} in both numerator and denominator.