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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{18az^{4}}{27az}\right)x^{2-5})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{2z^{3}}{3}\right)x^{-3})
Do the arithmetic.
-3\left(-\frac{2z^{3}}{3}\right)x^{-3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
2z^{3}x^{-4}
Do the arithmetic.
\frac{-2z^{3}}{3x^{3}}
Cancel out 9azx^{2} in both numerator and denominator.