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Evaluate
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Differentiate w.r.t. u
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\frac{-6v^{-4}\times \frac{1}{t}u^{4}}{t^{-3}v^{5}}
Cancel out 2u in both numerator and denominator.
\frac{-6v^{-4}t^{2}u^{4}}{v^{5}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{-6t^{2}u^{4}}{v^{9}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.